Computational quality control tools for mass spectrometry proteomics
نویسندگان
چکیده
منابع مشابه
Computational quality control tools for mass spectrometry proteomics.
As mass-spectrometry-based proteomics has matured during the past decade, a growing emphasis has been placed on quality control. For this purpose, multiple computational quality control tools have been introduced. These tools generate a set of metrics that can be used to assess the quality of a mass spectrometry experiment. Here we review which types of quality control metrics can be generated,...
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Mass Spectrometry is the tool of choice for Proteomics, with applications to peptide sequencing, protein structure prediction, protein-protein interactions, and many others. Continued improvements in instrumentation and computational technologies will only help accelerate this trend. A short overview of algorithms for interpreting mass spectrometry (MS) data is provided. This overview is not in...
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SUMMARY Quality control in mass spectrometry-based proteomics remains subjective, labor-intensive and inconsistent between laboratories. We introduce Metriculator, a software designed to facilitate long-term storage of extensive performance metrics as introduced by NIST in 2010. Metriculator features a web interface that generates interactive comparison plots for contextual understanding of met...
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In the late 1980s, the advent of soft ionization techniques capable of generating stable gas phase ions from thermally unstable biomolecules, namely matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI), laid the way for the development of a set of powerful alternatives to the traditional Edman chemistry for the structural characterization of peptides and protein...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2016
ISSN: 1615-9853
DOI: 10.1002/pmic.201600159